1 resultado para Neoplasm Invasiveness
em WestminsterResearch - UK
Filtro por publicador
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (10)
- Aquatic Commons (3)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (4)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (4)
- Biblioteca de Teses e Dissertações da USP (6)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (35)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (6)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (6)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (71)
- CaltechTHESIS (2)
- CentAUR: Central Archive University of Reading - UK (5)
- Centro Hospitalar do Porto (4)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (4)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- Deakin Research Online - Australia (17)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (18)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (3)
- DigitalCommons@The Texas Medical Center (31)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Duke University (28)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (11)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Glasgow Theses Service (2)
- Helda - Digital Repository of University of Helsinki (4)
- Indian Institute of Science - Bangalore - Índia (4)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Politécnico do Porto, Portugal (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (3)
- National Center for Biotechnology Information - NCBI (18)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (147)
- Queensland University of Technology - ePrints Archive (140)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (5)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositorio de la Universidad de Cuenca (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (234)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- Scielo España (1)
- Scientific Open-access Literature Archive and Repository (7)
- Universidad del Rosario, Colombia (8)
- Universidad Politécnica de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (7)
- Universidade Federal de Uberlândia (1)
- Universidade Federal do Pará (8)
- Universidade Federal do Rio Grande do Norte (UFRN) (16)
- Universidade Técnica de Lisboa (1)
- Université de Lausanne, Switzerland (35)
- Université de Montréal (1)
- Université de Montréal, Canada (5)
- University of Michigan (1)
- University of Queensland eSpace - Australia (12)
- University of Washington (2)
- WestminsterResearch - UK (1)
Resumo:
Hairy and enhancer of split homolog-1 (HES1) is a part of an extensive family of basic helix-loop-helix (bHLH) proteins and plays a crucial role in the control and regulation of cell cycle, proliferation, cell differentiation, survival and apoptosis in neuronal, endocrine, T-lymphocyte progenitors as well as various cancers. HES1 is a transcription factor which is regulated by the NOTCH, Hedgehog and Wnt signalling pathways. Aberrant expression of these pathways is a common feature of cancerous cells. There appears to be a fine and complicated crosstalk at the molecular level between the various signalling pathways and HES1, which contributes to its effects on the immune response and cancers such as leukaemia. Several mechanisms have been proposed, including an enhanced invasiveness and metastasis by inducing epithelial mesenchymal transition (EMT), in addition to its strict requirement for tumour cell survival. In this review, we summarize the current biology and molecular mechanisms as well as its use as a clinical target in cancer therapeutics.